I’ve also been told that my candida strain has grown resistant to chemical drugs. I am not a negative person at all, but I can honestly tell you I have had it. I am always tired and really fed up with this. Please tell me there is something more I can do. Some types of Candida are increasingly resistant to the first-line and second-line antifungal medications, such as fluconazole and the echinocandins (anidulafungin, caspofungin, and micafungin). About 7% of all Candida bloodstream isolates (pure samples of a germ) tested at CDC are resistant to fluconazole. The percentage of clotrimazole- and fluconazole- resistant isolates was found to be similar in both superficial infections and blood infections with 63% of resistant isolates in blood infections vs. 64.9% of resistant isolates in superficial infections for clotrimazole, and 7.4% resistant isolates in blood infections and 6.3% isolates resistant in superficial infections for fluconazole. Is it possible for fungi to become resistant to clotrimazole? I've used clotrimazole topical cream two times before for candida infection and it was effective. I have candida again, after two years and immediately went for the clotrimazole. What to do if Clotrimazole doesn’t Work? If you don’t see any improvement after you finish your clotrimazole treatment it may be because your infection is caused by a Candida strain resistant to clotrimazole. Treating fluconazole-resistant thrush. The symptoms of azole-resistant candidiasis do not differ significantly from those of the more treatable forms of thrush, but they do tend to be more severe. Previous studies correlating susceptibility test results of Candida species for azoles with clinical outcome support the “90-60 rule” established for bacterial infections: approximately 90% of infections due to susceptible isolates respond, while infections due to resistant isolates respond approximately 60% of the time. Le candida albicans est un organisme diploïde, c’est une espèce de levure qui se trouve généralement sur la peau et la muqueuse buccale ou vaginale et au sein de l’estomac. Les infections des muqueuses à candida glabrata comme le muguet et l’œsophagite sont généralement bénignes et peuvent être traitées avec des antifongiques par voie orale telles que le clotrimazole, le flucanozole, l’itraconazole, la nystatine et l’amphotéricine B.